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Article

Origin of conformational dynamics in a globular protein.

Communications biology - 1 Jan 2019

Damry Adam M, Mayer Marc M, Broom Aron, Goto Natalie K, Chica Roberto A

Abstract excerpt

Protein structures are dynamic, undergoing motions that can play a vital role in function. However, the link between primary sequence and conformational dynamics remains poorly understood. Here, we studied how conformational dynamics can arise in a globular protein by evaluating the impact of individual core-residue substitutions in DANCER-3, a streptococcal protein G domain β1 variant that we previously designed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31799435
DOI: 10.1038/s42003-019-0681-2
PMCID: PMC6879633

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