Article
Integration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2017
Reid Brett M, Permuth Jennifer B, Chen Y Ann, Teer Jamie K, Monteiro Alvaro N A, Chen Zhihua, Tyrer Jonathan, Berchuck Andrew, Chenevix-Trench Georgia, Doherty Jennifer A, Goode Ellen L, Iverson Edwin S, Lawrenson Kate, Pearce Celeste L, Pharoah Paul D, Phelan Catherine M, Ramus Susan J, Rossing Mary Anne, Schildkraut Joellen M, Cheng Jin Q, Gayther Simon A, Sellers Thomas A
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified multiple loci associated with epithelial ovarian cancer (EOC) susceptibility, but further progress requires integration of epidemiology and biology to illuminate true risk loci below genome-wide significance levels (P < 5 × 10-8). Most risk SNPs lie within non-protein-encoding regions, and we hypothesize that long noncoding RNA (lncRNA) genes are...
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