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Article

Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase.

The Journal of biological chemistry - 28 Oct 2011

Asim Mohammad, Hafeez Bilal Bin, Siddiqui Imtiaz Ahmad, Gerlach Claudia, Patz Michaela, Mukhtar Hasan, Baniahmad Aria

Abstract excerpt

The activated androgen receptor (AR) promotes prostate cancer (PCa) growth. AR antagonists repress the AR by recruitment of corepressors. Not much is known about the inactivation of AR by corepressors in the presence of agonists (androgens). Here we show that the corepressor LCoR acts as an androgen-dependent corepressor that represses human PCa growth in vivo. In line with this, progressive decrease of...

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Identifiers

PMID: 21856747
DOI: 10.1074/jbc.M111.292771
PMCID: PMC3199458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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