Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hey1, a Mediator of Notch Signaling, Is an Androgen Receptor Corepressor

1 Feb 2005

Abstract excerpt

Hey1 is a member of the basic helix-loop-helix-Orange family of transcriptional repressors that mediate Notch signaling. Here we show that transcription from androgen-dependent target genes is inhibited by Hey1 and that expression of a constitutively active form of Notch is capable of repressing transactivation by the endogenous androgen receptor (AR). Our results indicate that Hey1 functions as a corepressor for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15684393
DOI: 10.1128/mcb.25.4.1425-1436.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hey1, a Mediator of Notch Signaling, Is an Androgen Receptor CorepressorPMID 15684393Read ↗

Repression of Androgen Receptor Activity by HEYL, a Third Member of the Hairy/Enhancer-of-split-related Family of Notch EffectorsSemantic proximity Read ↗

Androgen receptor (AR) coregulators: an overview.Semantic proximity Read ↗

Comparative Analysis of the Human and Mouse Hey1 Promoter: Hey Genes Are New Notch Target GenesSemantic proximity Read ↗

Androgen Receptor (AR) Coregulators: An OverviewSemantic proximity Read ↗

RUNX1, an androgen- and EZH2-regulated gene, has differential roles in AR-dependent and -independent prostate cancerSemantic proximity Read ↗

FoxA1 is a Key Mediator of Hormonal Response in Breast and Prostate CancerSemantic proximity Read ↗

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progressionSemantic proximity Read ↗

Regulation of Androgen Receptor-dependent Transcription by Coactivator MED1 Is Mediated through a Newly Discovered Noncanonical Binding MotifSemantic proximity Read ↗

A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor.Semantic proximity Read ↗

FOXA1: a transcription factor with parallel functions in development and cancerSemantic proximity Read ↗

Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer ProgressionSemantic proximity Read ↗

HEY1 Leu94Met gene polymorphism dramatically modifies its biological functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.