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Article

Fused in Sarcoma Neuropathology in Neurodegenerative Disease.

Cold Spring Harbor perspectives in medicine - 1 Dec 2017

Mackenzie Ian R A, Neumann Manuela

Abstract excerpt

Abnormal intracellular accumulation of the fused in sarcoma (FUS) protein is the characteristic pathological feature of cases of familial amyotrophic lateral sclerosis (ALS) caused by FUS mutations (ALS-FUS) and several uncommon disorders that may present with sporadic frontotemporal dementia (FTLD-FUS). Although these findings provide further support for the concept that ALS and FTD are closely related clinical...

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Source

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Identifiers

PMID: 28096243
DOI: 10.1101/cshperspect.a024299
PMCID: PMC5710099

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Fused in Sarcoma Neuropathology in Neurodegenerative Disease.PMID 28096243Read ↗

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FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.Semantic proximity Read ↗

Importance of Functional Loss of FUS in FTLD/ALSSemantic proximity Read ↗

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration.Semantic proximity Read ↗

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