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Research development and the prospect of animal models of mitochondrial DNA-related mitochondrial diseases.

Analytical biochemistry - 15 May 2023

Wang Xiaolei, Lu Hedong, Li Min, Zhang Zhiguo, Wei Zhaolian, Zhou Ping, Cao Yunxia, Ji Dongmei, Zou Weiwei

Abstract excerpt

Mitochondrial diseases (MDs) are genetic and clinical heterogeneous diseases caused by mitochondrial oxidative phosphorylation defects. It is not only one of the most common genetic diseases, but also the only genetic disease involving two different genomes in humans. As a result of the complicated genetic condition, the pathogenesis of MDs is not entirely elucidated at present, and there is a lack of effective...

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PMID: 36948236
DOI: 10.1016/j.ab.2023.115122

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