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Article

Variance of gene expression identifies altered network constraints in neurological disease.

PLoS genetics - 1 Aug 2011

Mar Jessica C, Matigian Nicholas A, Mackay-Sim Alan, Mellick George D, Sue Carolyn M, Silburn Peter A, McGrath John J, Quackenbush John, Wells Christine A

Abstract excerpt

Gene expression analysis has become a ubiquitous tool for studying a wide range of human diseases. In a typical analysis we compare distinct phenotypic groups and attempt to identify genes that are, on average, significantly different between them. Here we describe an innovative approach to the analysis of gene expression data, one that identifies differences in expression variance between groups as an...

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Identifiers

PMID: 21852951
DOI: 10.1371/journal.pgen.1002207
PMCID: PMC3154954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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