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Article

A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence.

PLoS pathogens - 5 Oct 2007

Conenello Gina M, Zamarin Dmitriy, Perrone Lucy A, Tumpey Terrence, Palese Peter

Abstract excerpt

The proapoptotic PB1-F2 protein of influenza A viruses has been shown to contribute to pathogenesis in the mouse model. Expression of full-length PB1-F2 increases the pathogenesis of the influenza A virus, causing weight loss, slower viral clearance, and increased viral titers in the lungs. After comparing viruses from the Hong Kong 1997 H5N1 outbreak, one amino acid change (N66S) was found in the PB1-F2 sequence...

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Source

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Identifiers

PMID: 17922571
DOI: 10.1371/journal.ppat.0030141
PMCID: PMC2000966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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