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Article

Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses.

Virus research - 5 Dec 2013

Smith Amber M, McCullers Jonathan A

Abstract excerpt

The PB1-F2 protein of influenza A viruses contributes to pathogenesis in animal models. Specific molecular signatures of virulence within PB1-F2 have been mapped for some functions. The 66S polymorphism may modulate interferon activity, and four C-terminal amino acids, 62L, 75R, 79R, and 82L, contribute to cytokine release and inflammatory responses in specific virus backgrounds. All available PB1-F2 sequences...

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Identifiers

PMID: 23499672
DOI: 10.1016/j.virusres.2013.02.012
PMCID: PMC4006689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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