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Evolution and Virulence of Influenza A Virus Protein PB1-F2

29 Dec 2017

Abstract excerpt

PB1-F2 is an accessory protein of most human, avian, swine, equine, and canine influenza A viruses (IAVs). Although it is dispensable for virus replication and growth, it plays significant roles in pathogenesis by interfering with the host innate immune response, inducing death in immune and epithelial cells, altering inflammatory responses, and promoting secondary bacterial pneumonia. The effects of PB1-F2...

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PMID: 29286299
DOI: 10.3390/ijms19010096

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