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Article

PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens.

PloS one - 1 Jan 2014

Leymarie Olivier, Embury-Hyatt Carissa, Chevalier Christophe, Jouneau Luc, Moroldo Marco, Da Costa Bruno, Berhane Yohannes, Delmas Bernard, Weingartl Hana M, Le Goffic Ronan

Abstract excerpt

Highly pathogenic avian influenza virus (HPAIV) is a permanent threat due to its capacity to cross species barriers and generate severe infections and high mortality in humans. Recent findings have highlighted the potential role of PB1-F2, a small accessory influenza protein, in the pathogenesis process mediated by HPAIV in mammals. In this study, using a recombinant H5N1 HPAIV (wt) and its PB1-F2-deleted mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24959667
DOI: 10.1371/journal.pone.0100679
PMCID: PMC4069075

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