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Article

Differential localization and function of PB1-F2 derived from different strains of influenza A virus.

Journal of virology - 1 Oct 2010

Chen Chi-Jene, Chen Guang-Wu, Wang Ching-Ho, Huang Chih-Heng, Wang Yeau-Ching, Shih Shin-Ru

Abstract excerpt

PB1-F2 is a viral protein that is encoded by the PB1 gene of influenza A virus by alternative translation. It varies in length and sequence context among different strains. The present study examines the functions of PB1-F2 proteins derived from various human and avian viruses. While H1N1 PB1-F2 was found to target mitochondria and enhance apoptosis, H5N1 PB1-F2, surprisingly, did not localize specifically to...

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Identifiers

PMID: 20660199
DOI: 10.1128/JVI.00592-10
PMCID: PMC2937816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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