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Article

Roles for β-catenin and doxycycline in the regulation of respiratory epithelial cell frequency and function.

American journal of respiratory cell and molecular biology - 1 Jan 2012

Smith Russell W, Hicks Douglas A, Reynolds Susan D

Abstract excerpt

The expression of β-catenin-dependent genes can be increased through the Cre recombinase (Cre)-mediated elimination of the exon 3-encoded sequence. This mutant β-catenin is termed DE3, and promotes the expression of β-catenin-dependent genes. Our previous study used the DE3 model to demonstrate that persistent β-catenin activity inhibited bronchiolar Clara-to-ciliated cell differentiation. The present study was...

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Identifiers

PMID: 21852686
DOI: 10.1165/rcmb.2011-0099OC
PMCID: PMC3262653

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