Article
Haplotype-resolved genome sequencing of a Gujarati Indian individual.
Nature biotechnology - 1 Jan 2011
Kitzman Jacob O, Mackenzie Alexandra P, Adey Andrew, Hiatt Joseph B, Patwardhan Rupali P, Sudmant Peter H, Ng Sarah B, Alkan Can, Qiu Ruolan, Eichler Evan E, Shendure Jay
Abstract excerpt
Haplotype information is essential to the complete description and interpretation of genomes, genetic diversity and genetic ancestry. Although individual human genome sequencing is increasingly routine, nearly all such genomes are unresolved with respect to haplotype. Here we combine the throughput of massively parallel sequencing with the contiguity information provided by large-insert cloning to experimentally...
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