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Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population

18 Aug 2011

Abstract excerpt

The azoospermia factor c (AZFc) region on the Y chromosome is a genetically dynamic locus in the human genome. Numerous genomic rearrangements, including deletion, duplication and inversion, have been identified in AZFc. The complete deletion of AZFc can cause spermatogenic impairment. However, the roles of partial AZFc deletions (e.g. b2/b3 deletion) in spermatogenesis are controversial and variable among human...

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PMID: 21852246
DOI: 10.1093/hmg/ddr369

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Related research

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Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese populationPMID 21852246Read ↗

Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairmentSemantic proximity Read ↗

The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population.Semantic proximity Read ↗

Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertilitySemantic proximity Read ↗

A frequent Y chromosome b2/b3 subdeletion shows strong association with male infertility in Han-Chinese populationSemantic proximity Read ↗

Partial duplication at<i>AZFc</i>on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in TaiwanSemantic proximity Read ↗

DAZ duplications confer the predisposition of Y chromosome haplogroup K* to non-obstructive azoospermia in Han Chinese populations.Semantic proximity Read ↗

Partial AZFc duplications not deletions are associated with male infertility in the Yi population of Yunnan Province, China.Semantic proximity Read ↗

Association of partial AZFc region deletions with spermatogenic impairment and male infertility.Semantic proximity Read ↗

Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.Semantic proximity Read ↗

Common AZFc structure may possess the optimal spermatogenesis efficiency relative to the rearranged structures mediated by non-allele homologous recombination.Semantic proximity Read ↗

The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility.Semantic proximity Read ↗

The Association of Partial Azoospermia Factor C Deletions and Male Infertility in Northwestern ChinaSemantic proximity Read ↗

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