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Article

The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility.

Human reproduction update - 1 Jan 2000

Navarro-Costa Paulo, Gonçalves João, Plancha Carlos E

Abstract excerpt

BACKGROUND: The three azoospermia factor (AZF) regions of the Y chromosome represent genomic niches for spermatogenesis genes. Yet, the most distal region, AZFc, is a major generator of large-scale variation in the human genome. Determining to what extent this variability affects spermatogenesis is a highly contentious topic in human reproduction. METHODS: In this review, an extensive characterization of the...

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Share to Chromosome Deletion
Share to Chromosomes, Human, Y
Share to Gene Duplication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Infertility, Male

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Share to Recombination, Genetic

Share to Spermatogenesis

Source

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Identifiers

PMID: 20304777
DOI: 10.1093/humupd/dmq005
PMCID: PMC2918367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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