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Article

Association of partial AZFc region deletions with spermatogenic impairment and male infertility.

Journal of medical genetics - 1 Mar 2005

Ferlin A, Tessari A, Ganz F, Marchina E, Barlati S, Garolla A, Engl B, Foresta C

Abstract excerpt

BACKGROUND: Complete deletions of the AZFc region in distal Yq are the most frequent molecular genetic cause of severe male infertility. They are caused by intrachromosomal homologous recombination between amplicons--large, nearly identical repeats--and are found in 5-10% of cases of azoospermia and severe oligozoospermia. Homologous recombination may also generate different partial deletions of AZFc, but their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15744033
DOI: 10.1136/jmg.2004.025833
PMCID: PMC1736009

Genes

DAZ1
DAZ2
DAZ3
DAZ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of partial AZFc region deletions with spermatogenic impairment and male infertility.PMID 15744033Read ↗

Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertilitySemantic proximity Read ↗

Partial deletions in the AZFc region of the Y chromosome occur in men with impaired as well as normal spermatogenesisSemantic proximity Read ↗

Y-chromosome AZFc structural architecture and relationship to male fertility.Semantic proximity Read ↗

The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility.Semantic proximity Read ↗

Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility.Semantic proximity Read ↗

Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese populationSemantic proximity Read ↗

Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairmentSemantic proximity Read ↗

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Partial AZFc duplications not deletions are associated with male infertility in the Yi population of Yunnan Province, China.Semantic proximity Read ↗

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AZF deletions and Y chromosomal haplogroups: history and update based on sequenceSemantic proximity Read ↗

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