Article
Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicans.
Gene - 15 Mar 1990
Kelly R, Miller S M, Lai M H, Kirsch D R
Abstract excerpt
2,3-Oxidosqualene (OS) cyclase (OSC) catalyzes the conversion of OS to lanosterol, an essential step in the biosynthesis of sterols. The Candida albicans gene (ERG7) encoding OSC was cloned by complementation of a Saccharomyces cerevisiae OSC mutant (erg7). Two different Erg+ clones were isolated...
Topics
- Alleles
- Candida albicans
- Chromatography, Thin Layer
- Genes, Fungal
- Genetic Complementation Test
- Intramolecular Transferases
- Isomerases
- Mutation
- Restriction Mapping
- Transformation, Genetic