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Article

Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase.

Molecular and cellular biology - 1 Feb 1991

Tsay Y H, Robinson G W

Abstract excerpt

Saccharomyces cerevisiae strains that contain the ery8-1 mutation are temperature sensitive for growth due to a defect in phosphomevalonate kinase, an enzyme of isoprene and ergosterol biosynthesis. A plasmid bearing the yeast ERG8 gene was isolated from a YCp50 genomic library by functional complementation of the erg8-1 mutant strain. Genetic analysis demonstrated that integrated copies of an ERG8 plasmid mapped...

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Identifiers

PMID: 1846667
DOI: 10.1128/mcb.11.2.620-631.1991
PMCID: PMC359713

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