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Article

Mechanisms and implications of the age‐associated decrease in DNA repair capacity

1 Jul 2000

Abstract excerpt

Skin cancer incidence is clearly linked to UV irradiation and increases exponentially with age. We studied the rate of removal of thymine dimers and (6–4) photoproducts in UV‐irradiated human dermal fibroblasts derived from donors of different ages. There was a significant decrease with aging in the repair rates of both thymine dimers and (6–4) photoproducts ( P < 0.001). In addition, there was an...

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Identifiers

PMID: 10877825
DOI: 10.1096/fasebj.14.10.1325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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