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Article

Metabolic imaging: a link between lactate dehydrogenase A, lactate, and tumor phenotype.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2011

Serganova Inna, Rizwan Asif, Ni Xiaohui, Thakur Sunitha B, Vider Jelena, Russell James, Blasberg Ronald, Koutcher Jason A

Abstract excerpt

PURPOSE: We compared the metabolic profiles and the association between LDH-A expression and lactate production in two isogenic murine breast cancer cell lines and tumors (67NR and 4T1). These cell lines were derived from a single mammary tumor and have different growth and metabolic phenotypes. EXPERIMENTAL DESIGN: LDH-A expression, lactate concentration, glucose utilization, and oxygen consumption were measured...

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Identifiers

PMID: 21844011
DOI: 10.1158/1078-0432.CCR-11-0397
PMCID: PMC4217119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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