Article
Genetic toxicity of the benzene metabolite trans, trans-muconaldehyde in mammalian and bacterial cells.
Mutation research - 1 Apr 1990
Witz G, Gad S C, Tice R R, Oshiro Y, Piper C E, Goldstein B D
Abstract excerpt
Previous studies in our laboratory identified trans,trans-muconaldehyde (MUC), a six-carbon diene dialdehyde, as a microsomal metabolite of benzene. This ring-opened metabolite of benzene was also shown to be hematotoxic in mice in a manner similar to benzene. To further explore the role of MUC i...
Topics
- Aldehydes
- Animals
- Bone Marrow
- Cell Line
- Cells, Cultured
- Cricetinae
- Dose-Response Relationship, Drug
- Hypoxanthine Phosphoribosyltransferase
- Liver
- Mice
- Micronuclei, Chromosome-Defective
- Micronucleus Tests
- Mutagenicity Tests
- Mutation
- Salmonella typhimurium
- Sister Chromatid Exchange