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Article

Importance of domain closure for the autoactivation of ERK2.

Biochemistry - 20 Sept 2011

Barr Daniel, Oashi Taiji, Burkhard Kimberly, Lucius Sarah, Samadani Ramin, Zhang Jun, Shapiro Paul, MacKerell Alexander D, van der Vaart Arjan

Abstract excerpt

Extracellular signal-regulated kinases 1 and 2 (ERK1 and -2, respectively) play a critical role in regulating cell division and have been implicated in cancer. In addition to activation by MAPK/ERK kinases 1 and 2 (MEK1 and -2, respectively), certain mutants of ERK2 can be activated by autophosphorylation. To identify the mechanism of autoactivation, we have performed a series of molecular dynamics simulations of...

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Identifiers

PMID: 21842857
DOI: 10.1021/bi200503a
PMCID: PMC3172398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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