Article
MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.
Cancer discovery - 1 Jun 2015
Nowak Dawid G, Cho Hyejin, Herzka Tali, Watrud Kaitlin, DeMarco Daniel V, Wang Victoria M Y, Senturk Serif, Fellmann Christof, Ding David, Beinortas Tumas, Kleinman David, Chen Muhan, Sordella Raffaella, Wilkinson John E, Castillo-Martin Mireia, Cordon-Cardo Carlos, Robinson Brian D, Trotman Lloyd C
Abstract excerpt
UNLABELLED: We have recently recapitulated metastasis of human PTEN/TP53-mutant prostate cancer in the mouse using the RapidCaP system. Surprisingly, we found that this metastasis is driven by MYC, and not AKT, activation. Here, we show that cell-cell communication by IL6 drives the AKT-MYC switch through activation of the AKT-suppressing phosphatase PHLPP2, when PTEN and p53 are lost together, but not...
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