Article
A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome.
The Journal of nutrition - 1 Jul 2012
Garcia-Rios Antonio, Perez-Martinez Pablo, Delgado-Lista Javier, Phillips Catherine M, Gjelstad Ingrid M F, Wright John W, Karlström Brita, Kiec-Wilk Beata, van Hees A M J, Helal Olfa, Polus Anna, Defoort Catherine, Riserus Ulf, Blaak Ellen E, Lovegrove Julie A, Drevon Christian A, Roche Helen M, Lopez-Miranda Jose
Abstract excerpt
Genetic variants of Period 2 (PER2), a circadian clock gene, have been linked to metabolic syndrome (MetS). However, it is still unknown whether these genetic variants interact with the various types of plasma fatty acids. This study investigated whether common single nucleotide polymorphisms (SNPs) in the PER2 locus (rs934945 and rs2304672) interact with various classes of plasma fatty acids to modulate plasma...
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