Article
Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Salomon Dor, Zhang Chao, Shokat Kevan M, Sessa Guido
Abstract excerpt
The highly conserved nature of the protein kinase catalytic domain and the low permeability of plant cell membranes pose a challenge to the development of specific inhibitors that target individual protein kinases in vivo. Here, we describe a chemical-genetic approach to specifically sensitize in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
