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Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

19 Oct 2014

Abstract excerpt

Type 2 immune responses are often associated with the expression of chitinase-like Ym proteins, but their role is unclear. Allen and colleagues show that Ym1 and Ym2 act on γδ T cells to increase their expression of IL-17A and enhance the recruitment of neutrophils. Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet...

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PMID: 25326751
DOI: 10.1038/ni.3023

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