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Annexin A2: biology and relevance to the antiphospholipid syndrome

30 Sept 2008

Abstract excerpt

Antiphospholipid antibodies (aPL), the majority of which are directed against beta(2)-glycoprotein I (beta(2)GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-beta(2)GPI-associated thrombosis has not been defined, and is likely multifactorial. However, accumulating evidence suggests an important role for endothelial cell activation with...

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PMID: 18827060
DOI: 10.1177/0961203308095329

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