Article
GNAS promotes inflammation-related hepatocellular carcinoma progression by promoting STAT3 activation.
Cellular & molecular biology letters - 1 Jan 2020
Ding Hongda, Zhang Xixia, Su Yang, Jia Changjun, Dai Chaoliu
Abstract excerpt
BACKGROUND: Hepatocellular carcinoma (HCC) is still the most common cause of cancer-related mortality worldwide and accumulating studies report that HCC is frequently linked to chronic inflammation. G-protein alpha-subunit (GNAS)-activating mutations have recently been reported to form a rare subgroup of inflammatory liver tumors. In this study, we investigated the roles of GNAS in inflammation-related HCC...
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