Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma.

doi:10.1089/gtmb.2010.0264

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Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma.

Genetic testing and molecular biomarkers - 1 Jan 2000

Wang Wen, Wang Jian, Song Haihan, Liu Jie, Song Bao, Cao Xuecheng

Abstract excerpt

BACKGROUND: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a potent immunoregulatory molecule that suppresses anti-tumor response by down-regulating T-cell activation. CTLA-4 gene +49G/A polymorphism (rs231775) has been reported to be associated with various cancers. OBJECTIVE: The objective of this study is to investigate the association between CTLA-4 gene +49G/A polymorphism and the susceptibility to...

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PMID: 21453059
DOI: 10.1089/gtmb.2010.0264

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