Article
Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase.
Molecular pharmacology - 1 Dec 1998
Fidock D A, Nomura T, Wellems T E
Abstract excerpt
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the spread of drug-resistant strains of the malaria parasite Plasmodium falciparum. Here we describe a transformation system, involving WR99210 selection of parasites transfo...
Topics
- Animals
- Antimalarials
- Folic Acid Antagonists
- Genetic Complementation Test
- Humans
- Hypoxanthine
- Inhibitory Concentration 50
- Methotrexate
- Mutation
- Plasmodium falciparum
- Proguanil
- Tetrahydrofolate Dehydrogenase
- Triazines