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Article

Methionine oxidation of Sup35 protein induces formation of the [PSI+] prion in a yeast peroxiredoxin mutant.

The Journal of biological chemistry - 11 Nov 2011

Sideri Theodora C, Koloteva-Levine Nadejda, Tuite Mick F, Grant Chris M

Abstract excerpt

The frequency with which the yeast [PSI(+)] prion form of Sup35 arises de novo is controlled by a number of genetic and environmental factors. We have previously shown that in cells lacking the antioxidant peroxiredoxin proteins Tsa1 and Tsa2, the frequency of de novo formation of [PSI(+)] is greatly elevated. We show here that Tsa1/Tsa2 also function to suppress the formation of the [PIN(+)] prion form of Rnq1....

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Source

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Identifiers

PMID: 21832086
DOI: 10.1074/jbc.M111.272419
PMCID: PMC3234717

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MSRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methionine oxidation of Sup35 protein induces formation of the [PSI+] prion in a yeast peroxiredoxin mutant.PMID 21832086Read ↗

Oxidative stress conditions increase the frequency of de novo formation of the yeast [PSI+] prion.Semantic proximity Read ↗

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Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.Semantic proximity Read ↗

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Rnq1: an epigenetic modifier of protein function in yeast.Semantic proximity Read ↗

Destabilizing interactions among [PSI(+)] and [PIN(+)] yeast prion variants.Semantic proximity Read ↗

Yeast prions assembly and propagation: contributions of the prion and non-prion moieties and the nature of assemblies.Semantic proximity Read ↗

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Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p.Semantic proximity Read ↗

The PNM2 mutation in the prion protein domain of SUP35 has distinct effects on different variants of the [PSI+] prion in yeast.Semantic proximity Read ↗

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