Article
Oxidative stress conditions increase the frequency of de novo formation of the yeast [PSI+] prion.
Molecular microbiology - 1 Apr 2015
Doronina Victoria A, Staniforth Gemma L, Speldewinde Shaun H, Tuite Mick F, Grant Chris M
Abstract excerpt
Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals and heritable traits in yeast. The molecular basis of how yeast and mammalian prions form spontaneously into infectious amyloid-like structures is poorly understood. We have explored the hypothesis that oxidative stress is a general trigger for prion formation using the yeast [PSI(+)] prion, which...
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