Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.

doi:10.1016/j.dld.2011.07.002

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Article

Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Dec 2011

Svicher Valentina, Cento Valeria, Salpini Romina, Mercurio Fabio, Fraune Maria, Beggel Bastian, Han Yue, Gori Caterina, Wittkop Linda, Bertoli Ada, Micheli Valeria, Gubertini Guido, Longo Roberta, Romano Sara, Visca Michela, Gallinaro Valentina, Marino Nicoletta, Mazzotta Francesco, De Sanctis Giuseppe Maria, Fleury Hervè, Trimoulet Pascale, Angelico Mario, Cappiello Giuseppina, Zhang Xin Xin, Verheyen Jens, Ceccherini-Silberstein Francesca, Perno Carlo Federico

Abstract excerpt

BACKGROUND: Impact of hepatitis B virus genetic barrier, defined as the number and type of nucleotide substitutions required to overcome drug/immune selective pressure, on drug-resistance/immune-escape development is unknown. METHODS: Genetic barrier was calculated according to Van de Vijver (200...

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PMID: 21831732
DOI: 10.1016/j.dld.2011.07.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21831732-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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