Article
Drug-resistant and immune-escape HBV mutants in HIV-infected hosts.
Antiviral therapy - 1 Jan 2010
Lacombe Karine, Boyd Anders, Gozlan Joel, Lavocat Fabien, Girard Pierre-Marie, Zoulim Fabien
Abstract excerpt
HIV-HBV-coinfected patients require optimal control of viral replication in order to prevent the development of severe comorbidities, such as liver cirrhosis and hepatocellular carcinoma. The genetic diversity of HBV is a poorly investigated factor of such viral replication in HIV-infected hosts. HBV genome diversity can be differentiated into two major aspects: genotypic and phenotypic. Genotypic diversity is...
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