Article
Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus.
Journal of virology - 1 May 1990
Earl P L, Hügin A W, Moss B
Abstract excerpt
The in vivo role of the proposed poxvirus early transcription termination signal TTTTTNT was confirmed by analysis of the RNA species made by recombinant vaccinia viruses. Premature transcription termination occurred following each of two TTTTTNT sequences present naturally within the coding regi...
Topics
- Animals
- Base Sequence
- Gene Products, env
- Genes, Regulator
- Genes, env
- HIV Antibodies
- HIV Antigens
- HIV-1
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Poxviridae
- RNA, Messenger
- Recombination, Genetic
- Terminator Regions, Genetic
- Transcription, Genetic