Article

Increased neurovirulence of omicron BA.5 and XBB variants over BA.1 in K18-hACE2 mice and human brain organoids

2022-12-25

Abstract excerpt

<h4>SUMMARY</h4> The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 and XBB remains controversial. We show that BA.5 and XBB isolates were significantly more pathogenic in K18-hACE2 mice than a BA.1 isolate, showing increased neuroinvasiveness, resulting in fulminant brain infection an...

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Literature Corpus work: 3d0987d8-5dec-5516-8834-28b54acb7c2d
DOI: 10.1101/2022.12.22.521696

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