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Article

Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins

14 May 2013

Abstract excerpt

The role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic tumor suppressor pathway that thwarts expansion of cells that have suffered oncogenic hits. Infections with human cancer viruses including human papillomaviruses (HPVs) and Epstein-Barr virus can...

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PMID: 23673719
DOI: 10.3390/v5051231

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