Article
Relationship Between 18F-FDG PET/CT Scans and KRAS Mutations in Metastatic Colorectal Cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Sept 2015
Kawada Kenji, Toda Kosuke, Nakamoto Yuji, Iwamoto Masayoshi, Hatano Etsuro, Chen Fengshi, Hasegawa Suguru, Togashi Kaori, Date Hiroshi, Uemoto Shinji, Sakai Yoshiharu
Abstract excerpt
UNLABELLED: Several studies have shown that KRAS mutations in colorectal cancer (CRC) result in the lack of response to anti-epidermal growth factor receptor-based therapy; thus, KRAS mutational testing has been incorporated into routine clinical practice. However, 1 limitation of this test is the heterogeneity of KRAS status, which can be either intratumoral heterogeneity within an individual primary CRC or...
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