Article
The LuxS-dependent quorum-sensing system regulates early biofilm formation by Streptococcus pneumoniae strain D39.
Infection and immunity - 1 Oct 2011
Vidal Jorge E, Ludewick Herbert P, Kunkel Rebekah M, Zähner Dorothea, Klugman Keith P
Abstract excerpt
Streptococcus pneumoniae is the leading cause of death in children worldwide and forms highly organized biofilms in the nasopharynx, lungs, and middle ear mucosa. The luxS-controlled quorum-sensing (QS) system has recently been implicated in virulence and persistence in the nasopharynx, but its role in biofilms has not been studied. Here we show that this QS system plays a major role in the control of S....
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