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Article

Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages

3 May 2012

Abstract excerpt

BACKGROUND: Macrophages, which are CD4 and CCR5 positive, can sustain HIV-1 replication for long periods of time. Thus, these cells play critical roles in the transmission, dissemination and persistence of viral infection. Of note, current antiviral therapies do not target macrophages efficiently. Previously, it was demonstrated that interactions between CCR5 and gp120 stimulate PKC. However, the PKC isozymes...

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PMID: 22554282
DOI: 10.1186/1742-4690-9-37

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