Article
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.
Diabetologia - 1 Nov 2011
Torekov S S, Ma L, Grarup N, Hartmann B, Hainerová I A, Kielgast U, Kissow H, Rosenkilde M, Lebl J, Witte D R, Jørgensen T, Sandbaek A, Lauritzen T, Madsen O D, Wang J, Linneberg A, Madsbad S, Holst J J, Hansen T, Pedersen O
Abstract excerpt
AIMS/HYPOTHESIS: The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits. METHODS: GCG was re-sequenced as a candidate gene in 865 European individuals. Twenty-nine variants were identified. Four variants that were considered to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.