Article
Analysis of European case-control studies suggests that common inherited variation in mitochondrial DNA is not involved in susceptibility to amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Jun 2012
Ingram Catherine J E, Weale Michael E, Plaster Christopher A, Morrison Karen E, Goodall Emily F, Pall Hardev S, Beck Marcus, Jablonka Sibylle, Sendtner Michael, Fisher Elizabeth M C, Bradman Neil, Kasperavičiūtė Dalia
Abstract excerpt
While some cases of familial ALS can be entirely attributed to known inherited variation, the majority (∼ 90%) are sporadic, where the cause(s) are not entirely understood. Both genetic and environmental factors may contribute to susceptibility. Mitochondrial damage, a common feature of neurodege...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.