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Article

Significance of borderline HbA2 levels in β thalassemia carrier screening.

Scientific reports - 30 Mar 2022

Colaco Stacy, Colah Roshan, Nadkarni Anita

Abstract excerpt

Increased HbA2 levels are the characteristic feature of β-thalassemia carriers. A subset of carriers however do not show HbA2 levels in the typical carrier range (≥ 4.0%) but show borderline HbA2 levels. As a result, these carriers escape diagnosis and carry the risk of having β-thalassemia major offspring. Borderline HbA2 values may occur as a consequence of mild β-thalassemia mutations, co-inherited...

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Identifiers

PMID: 35354866
DOI: 10.1038/s41598-022-09250-5
PMCID: PMC8969165

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