Article
In-Silico Computing of the Most Deleterious nsSNPs in HBA1 Gene.
PloS one - 1 Jan 2016
AbdulAzeez Sayed, Borgio J Francis
Abstract excerpt
BACKGROUND: α-Thalassemia (α-thal) is a genetic disorder caused by the substitution of single amino acid or large deletions in the HBA1 and/or HBA2 genes. METHOD: Using modern bioinformatics tools as a systematic in-silico approach to predict the deleterious SNPs in the HBA1 gene and its significant pathogenic impact on the functions and structure of HBA1 protein was predicted. RESULTS AND DISCUSSION: A total of...
Topics
- 3' Untranslated Regions
- 5' Untranslated Regions
- Amino Acid Sequence
- Amino Acid Substitution
- Computational Biology
- Computer Simulation
- Databases, Genetic
- Glycated Hemoglobin
- Humans
- Introns
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Polymorphism, Single Nucleotide
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Sequence Homology, Amino Acid