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Article

Impairment of tRNA processing by point mutations in mitochondrial tRNA(Leu)(UUR) associated with mitochondrial diseases.

FEBS letters - 21 Aug 1998

Rossmanith W, Karwan R M

Abstract excerpt

Several point mutations in mitochondrial tRNA genes have been linked to distinct clinical subgroups of mitochondrial diseases. A particularly large number of different mutations is found in the tRNA(Leu)(UUR) gene. We show that base substitutions at nucleotide position 3256, 3260, and 3271 of the...

Topics

Anticodon
Base Sequence
Codon
Endoribonucleases
Genetic Diseases, Inborn
Genetic Variation
Humans
Mitochondrial Myopathies
Molecular Sequence Data
Nucleic Acid Conformation
Point Mutation
RNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Catalytic

RNA, Mitochondrial

RNA, Transfer, Leu

Ribonuclease P

Source

Identifiers

PMID: 9744809
DOI: 10.1016/s0014-5793(98)00928-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9744809-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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