Article
Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.
Nucleus (Austin, Tex.) - 1 Jan 2000
Kubben Nard, Voncken Jan Willem, Konings Gonda, van Weeghel Michel, van den Hoogenhof Maarten Mg, Gijbels Marion, van Erk Arie, Schoonderwoerd Kees, van den Bosch Bianca, Dahlmans Vivian, Calis Chantal, Houten Sander M, Misteli Tom, Pinto Yigal M
Abstract excerpt
A-type lamins are a major component of the nuclear lamina. Mutations in the LMNA gene, which encodes the A-type lamins A and C, cause a set of phenotypically diverse diseases collectively called laminopathies. While adult LMNA null mice show various symptoms typically associated with laminopathies, the effect of loss of lamin A/C on early post-natal development is poorly understood. Here we developed a novel LMNA...
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