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Article

A truncated lamin A in the Lmna -/- mouse line: implications for the understanding of laminopathies.

Nucleus (Austin, Tex.) - 1 Jan 2000

Jahn Daniel, Schramm Sabine, Schnölzer Martina, Heilmann Clemens J, de Koster Chris G, Schütz Wolfgang, Benavente Ricardo, Alsheimer Manfred

Abstract excerpt

During recent years a number of severe clinical syndromes, collectively termed laminopathies, turned out to be caused by various, distinct mutations in the human LMNA gene. Arising from this, remarkable progress has been made to unravel the molecular pathophysiology underlying these disorders. A great benefit in this context was the generation of an A-type lamin deficient mouse line (Lmna (-/-) ) by Sullivan and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22895093
DOI: 10.4161/nucl.21676
PMCID: PMC3474667

Genes

LMNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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