Article
[Laminopathies: one gene, several diseases].
Biologie aujourd'hui - 1 Jan 2011
Bertrand Anne T, Chikhaoui Khadija, Ben Yaou Rabah, Bonne Gisèle
Abstract excerpt
Lamins A and C, encoded by the LMNA gene, are nuclear proteins expressed in all post-mitotic cells. Together with B-type lamins, they form a meshwork of proteins beneath the inner nuclear membrane, the lamina, in connection with the cytoskeleton. Lamins A/C also interact with chromatin and numerous proteins, including transcription factors. Mutations in LMNA are responsible...
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