Article
A CRISPR/Cas9 zebrafish lamin A/C mutant model of muscular laminopathy.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2022
Nicolas Hannah A, Hua Khang, Quigley Hailey, Ivare Joshua, Tesson Frédérique, Akimenko Marie-Andrée
Abstract excerpt
BACKGROUND: Lamin A/C gene (LMNA) mutations frequently cause cardiac and/or skeletal muscle diseases called striated muscle laminopathies. We created a zebrafish muscular laminopathy model using CRISPR/Cas9 technology to target the zebrafish lmna gene. RESULTS: Heterozygous and homozygous lmna mutants present skeletal muscle damage at 1 day post-fertilization (dpf), and mobility impairment at 4 to 7 dpf. Cardiac...
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